Groopman received his BA and MD from Columbia College, Columbia University and was at the Massachusetts General Hospital for his internship and residency in internal medicine. This was followed by fellowships in hematology and oncology at the University of California and the Dana-Farber Cancer Institute in Boston.
Much of Groopman’s research has focused on the basic mechanisms of cancer and AIDS. He did seminal work on identifying growth factors which may restore the depressed immune systems of AIDS patients. He performed the first clinical trials in a technique that augments blood cell production in immunodeficient HIV-infected patients and has been a major participant in the development of many AIDS-related therapies including AZT. Recently, Groopman has extended the research infrastructure in genetics and cell biology to studies in breast cancer and neurobiology.
The first book written by Groopman was The Measure of Our Days, published in 1997. He also published Second Opinions in 2000 and Anatomy of Hope in 2004. His latest book, How Doctors Think, has rapidly risen to the top of the New York Times bestseller list since its release in March of 2007. Groopman was the guest editor for the 2008 edition of the yearly anthology The Best American Science and Nature Writing.